Welcome to Dr. Joshua Jacobs' Cognitive Brain Dynamics Lab at Drexel University

Research

The goal of our work is to characterize the neural signals that represent individual memories. To do this, we study brain recordings from epilepsy patients with implanted electrodes and examine how the recorded signals correspond to behavior in cognitive tasks. Our current work focuses on two areas: spatial and recognition memory. Using this approach, we have identified neural signals that represent specific memory information, including the individual locations in spatial memory and representations of individual verbal items in working memory.

Publications

    2014

  • Ritaccio, A., Brunner, P., Gunduz, A., Hermes, D., Hirsch, L., Jacobs, J., Kamada, K., Kastner, S., Knight, R., Lesser, R., Miller, K., Sejnowski, T., Worrell, G., Schalk, G. (2014). Proceedings of the Fifth International Workshop on Advances in Electrocorticography. Epilepsy & Behavior, 41, December 2014, 183-192. [pdf]
  • Misra, A., Burke, J.F., Ramayya, A., Jacobs, J., Sperling, M.R., Moxon, K.A., Kahana, M.J., Evans, J.J., and Sharan, A.D. (2014) Methods for implantation of micro-wire bundles and optimization of single/multi-unit recordings from human mesial temporal lobe. Journal of Neural Engineering, 11(2), 026013 [pdf]
  • Jacobs, J. (2014) Hippocampal theta oscillations are slower in humans than in rodents: Implications for models of spatial navigation and memory. Philosophical Transactions of the Royal Society B, 369: 20130304. [pdf]
  • 2013

  • Miller, J.F., Neufang, M., Solway, A., Brandt, A., Trippel, M., Mader, I., Polyn, S.M., Jacobs, J., Kahana, M.J., Schulze-Bonhage, A. (2013) Neural activity in human hippocampal formation reveals the spatial context of retrieved memories. Science, 342(6162), 1111-1114. [PDF, Supplemental]
  • Jacobs, J., Weidemann, C.T., Miller, J.F., Solway, A., Burke, J.F., Wei, X., Suthana, N., Sperling, M.R., Sharan, A.D., Fried, I., Kahana, M.J. (2013). Direct recordings of grid-like neuronal activity in human spatial navigation. Nature Neuroscience, 16, 1188-1190. [PDF, Supplemental,Task Movie]
  • Merzagora, A.R., Coffey, T.J, Sperling, M., Sharan, A., Litt., B, Baltuch, G., Jacobs, J. (2013). Repeated stimuli elicit diminished high-gamma electrocorticographic responses. NeuroImage. [pdf]
  • van Gerven, M.A.J., Maris, E., Sperling, M., Sharan, A., Litt, B., Anderson, C., Baltuch, G., Jacobs, J (2013). Decoding the memorization of individual stimuli with direct human brain recordings. NeuroImage, 70, 223-232. [pdf]
  • Burke, J.F., Zaghloul, K.A., Jacobs, J., Williams, R.B., Sperling, M.R., Sharan, A.D., Kahana., M.J. (2013). Synchronous and asynchronous theta and gamma activity during episodic memory formation. Journal of Neuroscience, 33(1), 292-304. [pdf]
  • 2012

  • Jacobs, J., Lega, B., Anderson, C. (2012). Explaining how brain stimulation can evoke memories. Journal of Cognitive Neuroscience, 24(3), 553-563. [pdf]
  • Lega, B., Jacobs, J, Kahana, M., (2012). Human hippocampal theta oscillations and the formation of episodic memories. Hippocampus, 22(4), 748-761. [pdf]
  • 2011

  • Jacobs, J., Miller, K., Edwards, E., Voytek, B. (2011). Spurious report of high-frequency electrocorticographic oscillations. [Electronic response to Nonuniform High-Gamma (60--500 Hz) Power Changes Dissociate Cognitive Task and Anatomy in Human Cortex., Gaona et al.] Journal of Neuroscience, Published online Feb. 28, 2011. [Link]
  • 2010

  • Jacobs, J., Manning, J.R., Kahana, M.J. (2010). Response to Miller: Broadband vs. high gamma electrocorticographic signals. Journal of Neuroscience, 30, online.
  • Jacobs, J., Kahana, M.J., Ekstrom, A.D., Mollison, M., & Fried, I. (2010). A sense of direction in human entorhinal cortex. Proceedings of the National Academy of Sciences, 107(14), 6487 – 6492. [PDF, Supplemental, Movie]
  • Jacobs, J., Kahana, M.J. (2010). Direct brain recordings fuel advances in cognitive electrophysiology. Trends in Cognitive Sciences, 14(4), 162 – 171. [PDF]
  • Jacobs, J.,∗ Korolev, I.O.,∗ Caplan, J.B., Ekstrom, A.D., Litt, B., Baltuch, G., Fried, I., Schulze-Bonhage, A., Madsen, J. R., & Kahana, M.J. (2010). Right-lateralized brain oscillations in human spatial navigation. Journal of Cognitive Neuroscience, 22(5), 824 – 836. (∗ equal contributions.) [PDF]
  • 2009

  • Manning, J.R., Jacobs, J., Fried, I., & Kahana, M.J. (2009). Broadband shifts in LFP power spectra are correlated with single-neuron activity in humans. Journal of Neuroscience, 29(43), 13613 – 3620. [PDF, Supplemental]
  • Jacobs, J., & Kahana, M.J. (2009). Neural representations of individual stimuli revealed by gamma-band electrocorticographic activity. Journal of Neuroscience, 29(33), 10203 – 10214. [PDF]
  • 2007

  • Geller, A.S., Schleifer, I.K., Sederberg, P.B., Jacobs, J., & Kahana, M.J. (2007). PyEPL: A cross-platform experiment-programming library. Behavior Research Methods, 39(4), 950 – 958. [PDF]
  • Ekstrom, A., Viskontas, I., Kahana, M.J., Jacobs, J., Upchurch, K., Bookheimer, S., & Fried, I. (2007). Contrasting roles of single neuron activity and local field potentials in human memory. Hippocampus, 17(8), 606 – 17. [PDF]
  • Jacobs, J., Kahana, M.J., Ekstrom, A.D. & Fried, I. (2007). Brain oscillations control timing of single-neuron activity in humans. Journal of Neuroscience, 27(14), 3839 – 3844. [PDF]
  • 2006 and earlier

  • Jacobs, J., Hwang-Grodzins, G., Curran, T., & Kahana, M.J. (2006). EEG oscillations and recognition memory: Theta correlates of memory retrieval and decision making. NeuroImage, 32, 978 – 987. [PDF]
  • Hwang-Grodzins, G., Jacobs, J., Geller, A., Danker, J., Sekuler, R., & Kahana, M.J. (2005). EEG correlates of verbal and nonverbal working memory. Behavioral and Brain Functions, 1 – 20. [PDF]
  • Kahana, M.J. & Jacobs, J. (2000). Inter-response times in serial recall: Effects of intraserial repetition. Journal of Experimental Psychology: Learning, Memory and Cognition, 26, 1188 – 1197. [PDF]